Tumor mutation burden (TMB) is a widely recognized stratification biomarker staff for predicting the efficacy of immunotherapy; however, the number and universal definition of the categorizing thresholds remain debatable due to the multifaceted nature of efficacy and the imprecision of TMB measurements.We proposed a minimal joint p-value criterion
Original Thinking
History that comes to us as a chronology of events is really a collective existence that is evolving through several stages to develop Individuality in all members of the society.The human community, nation states, linguistic groups, local castes and classes, and families are the intermediate stages in development of the Individual.The social LEAVE
Experimental Study on the Effects of Hydrogen Injection Strategy on the Combustion and Emissions of a Hydrogen/Gasoline Dual Fuel SI Engine under Lean Burn Condition
Hydrogen addition can improve the Knife tower performance and extend the lean burn limit of gasoline engines.Different hydrogen injection strategies lead to different types of hydrogen mixture distribution (HMD), which affects the engine performance.Therefore, the present study experimentally investigated the effects of hydrogen injection strategy
Acute Toxicity Assessment: Macroscopic and Ultrastructural Effects in Mice Treated with Oral Tetrodotoxin
Tetrodotoxin (TTX) is an extremely toxic marine PDF magazine compound produced by different genera of bacteria that can reach humans through ingestion mainly of pufferfish but also of other contaminated fish species, marine gastropods or bivalves.TTX blocks voltage-gated sodium channels inhibiting neurotransmission, which in severe cases triggers c